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Vaccinations are now considered a part of everyday life, but how do they work?

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Description

Vaccination is a course that will help those with a background in biology understand the historical development of vaccination, assess the various types of vaccines used today, examine their production and explore the limitations that are placed on vaccination programmes.

Course learning outcomes

After studying this course, you should be able to:

  • Define and use, or recognise definitions and applications of, each of the terms in bold in the course
  • Use examples from the history of vaccination to illustrate the conduct and outcomes of vaccine strategies to control infectious diseases
  • Discuss the principle strategies available for developing a vaccine and explain the significance of critical antigens, immunogens and adjuvants in developing effective vaccines
  • Identify examples of infectious diseases for which effective vaccines are available and some for which they are not. Explain why it has been scientifically difficult or commercially unprofitable to develop vaccines against certain infectious diseases, and why others have been amenable to control by vaccination
  • Discuss the prospects for developing a vaccine against a named infectious disease, given information on its biology and epidemiology, and on the immune response in human hosts.

Course content

  • Introduction 00:07:00
  • Learning outcomes 00:10:00
    • The smallpox virus 00:10:00
    • Variolation 00:20:00
    • Edward Jenner and vaccination with cowpox 00:25:00
    • Is smallpox still a threat? 00:15:00
    • Summary of Section 1 00:10:00
    • From passive to active 01:00:00
    • Summary of Section 2 00:07:00
    • How do vaccines work? 00:30:00
    • Summary of Section 3 00:05:00
    • Introduction 00:25:00
    • Intact killed pathogens 00:20:00
    • Attenuated pathogens 00:30:00
    • Subunit vaccines 00:15:00
    • Vaccines of the future 01:00:00
    • Summary of Section 4 00:10:00
    • Introduction 00:05:00
    • Antigens and immunogens 00:50:00
    • Adjuvants 00:30:00
    • Summary of Section 5 00:07:00
    • Introduction 00:20:00
    • Zoonoses 00:20:00
    • Asymptomatic carriers 00:10:00
    • Evasion of the immune response 00:25:00
    • Multiple strains 00:10:00
    • Prion diseases 00:15:00
    • Conclusion 00:15:00
    • Summary of Section 6 00:10:00
    • Introduction 00:10:00
    • Cost-effectiveness 00:30:00
    • Organisational difficulties 00:25:00
    • Vaccine safety 00:20:00
    • Perceived risk of vaccination 00:45:00
    • Summary of Section 7 00:10:00
    • nternet researches into vaccination issues 00:30:00
    • Conclusion 00:03:00

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