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September 23, 2023

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This course includes:

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Description

Chemistry 125: Advanced Organic Chemistry (Spring 2016, UC Irvine). Instructor: Professor James S. Nowick.

The course builds upon the concepts and skills learned in a typical year long sophomore-level organic chemistry class. Topics include: The Chemical Literature and Databases; Stereochemistry and Structural Organic Chemistry; Synthetic Organic Chemistry; Mechanistic and Physical Organic Chemistry; NMR Spectroscopy. The course follows closely to the textbook Intermediate Organic Chemistry, 3rd edition, by Ann M. Fabirkiewicz and John C. Stowell.

Course Curriculum

  • Lecture 01 – Nomenclature: Bicyclic Compounds Unlimited
  • Lecture 02 – Spirocyclic Compounds, Polycyclic Hydrocarbons, and Heterocyclic Compounds Unlimited
  • Lecture 03 – Databases and the Chemical Literature Unlimited
  • Lecture 04 – Stereochemistry: Properties of Stereoisomers Unlimited
  • Lecture 05 – Concepts in Stereochemistry Unlimited
  • Lecture 06 – Stereoselectivity in the Aldol Reaction Unlimited
  • Lecture 07 – Organic Reaction Mechanisms Unlimited
  • Lecture 08 – Reaction Kinetics Unlimited
  • Lecture 09 – Effect of Activation Energies and Temperature on Reaction Rates: The Eyring Equation Unlimited
  • Lecture 10 – Linear Free-Energy Relationships, The Kinetic Isotope Effect Unlimited
  • Lecture 11 – Molecular Orbitals and Aromaticity Unlimited
  • Lecture 12 – Introduction to Pericyclic Reactions, Electrocyclic Reactions Unlimited
  • Lecture 13 – Pericyclic Reactions: Cycloadditions and Sigmatropic Rearrangements Unlimited
  • Lecture 14 – Functional Group Transformations: The Importance of Oxidation State Unlimited
  • Lecture 15 – Oxidation and Reduction of Alcohols and Carbonyl Compounds Unlimited
  • Lecture 16 – Stereoselective Reduction; Mitsunobu Reaction; Barton-McCombie Deoxygenation Unlimited
  • Lecture 17 – Carbon-Carbon Bond Forming Reactions: The Importance of the Carbonyl Group Unlimited
  • Lecture 18 – Claisen Condensation and Michael Addition Unlimited
  • Lecture 19 – Acid-Catalyzed Aldol Reactions and the Mannich Reaction Unlimited
  • Lecture 20 – Enamines, the Wittig Reaction, and Cyclopropanation Unlimited
  • Lecture 21 – Benzoin Condensation, Acyl Anion Equivalents, and the Acyloin Condensation Unlimited
  • Lecture 22 – Retrosynthetic Analysis, The Diels-Alder Reaction and the Robinson Annulation Unlimited
  • Lecture 23 – Effects of Concentration, Stoichiometry, and Other Reaction Conditions Unlimited
  • Lecture 24 – How Temperature and Other Conditions Affect Reactions Unlimited
  • Lecture 25 – NMR Spectroscopy: How NMR Works, Chemical Shifts Unlimited
  • Lecture 26 – Spin-Spin Coupling in 1H NMR Spectroscopy Unlimited
  • Lecture 27 – Determining Stereochemistry and Regiochemistry by NMR Unlimited
  • Lecture 28 – 13C-NMR Spectroscopy, Introduction to 2D NMR, COSY and HMQC Unlimited

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