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September 26, 2023

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This course includes:

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Description

Biology W3310: Virology (Spring 2012, Columbia University). Instructor: Professor Vincent Racaniello. The basic thesis of the course is that all viruses adopt a common strategy.

The strategy is simple:
1. Viral genomes are contained in metastable particles.
2. Genomes encode gene products that promote an infectious cycle (mechanisms for genomes to enter cells, replicate, and exit in particles).
3. Infection patterns range from benign to lethal; infections can overcome or co-exist with host defenses.

The course will emphasize the common reactions that must be completed by all viruses for successful reproduction within a host cell and survival and spread within a host population. The molecular basis of alternative reproductive cycles, the interactions of viruses with host organisms, and how these lead to disease are presented with examples drawn from a set of representative animal and human viruses, although selected bacterial viruses will be discussed.

Course Curriculum

  • Lecture 01 – What Is a Virus? Unlimited
  • Lecture 02 – The Infectious Cycle Unlimited
  • Lecture 03 – Genomes and Genetics Unlimited
  • Lecture 04 – Structure of Viruses Unlimited
  • Lecture 05 – Attachment and Entry Unlimited
  • Lecture 06 – RNA-directed RNA Synthesis Unlimited
  • Lecture 07 – Replication of DNA Virus Genomes Unlimited
  • Lecture 08 – Transcription from DNA Virus Genomes Unlimited
  • Lecture 09 – Reverse Transcription and Integration Unlimited
  • Lecture 10 – Translation Unlimited
  • Lecture 11 – Assembly Unlimited
  • Lecture 12 – Infection Basics Unlimited
  • Lecture 13 – Host Defense Unlimited
  • Lecture 14 – Viral Evasion Strategies Unlimited
  • Lecture 15 – Virus-Host Interactions Unlimited
  • Lecture 16 – Persistent Infections Unlimited
  • Lecture 17 – Acute Infections Unlimited
  • Lecture 18 – HIV Pathogenesis Unlimited
  • Lecture 19 – Transformation and Oncogenesis Unlimited
  • Lecture 20 – Vaccines Unlimited
  • Lecture 21 – Antivirals Unlimited
  • Lecture 22 – Evolution Unlimited
  • Lecture 23 – Emerging Viruses Unlimited
  • Lecture 24 – Usual Infectious Agents Unlimited
  • Lecture 25 – XMRV Unlimited
  • Lecture 26 – H5N1 Unlimited

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