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Last updated:

September 24, 2022


Unlimited Duration


This course includes:

Unlimited Duration

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Certificate of completion

Unlimited Duration


This course covers the principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering.

Methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. Mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Tissue and organ regeneration. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.

Course Curriculum

    • Survey of clinical cases of biomaterials-tissue interactions Unlimited
    • Tissue structures and unit cell processes Unlimited
    • Unit cell processes comprising the healing response Unlimited
    • Unit cell processes underlying tissue engineering Unlimited
    • Structure and function of naturally occurring ECMs Unlimited
    • ECM does not regenerate spontaneously Unlimited
    • Analysis of surfaces of biomaterials and protein adsorption Unlimited
    • Phenotype changes following adhesion on biomaterials Unlimited
    • Structural determinants of biologically active materials Unlimited
    • Methodology for cell-surface interactions Unlimited
    • Cell-scaffold interactions during regeneration Unlimited
    • Noncooperative cell-surface interactions Unlimited
    • From randomness to cooperativity Unlimited
    • Tissue response to implants; biocompatibility Unlimited
    • Epithelialization (epidermal regeneration) and endothelialization of vascular prostheses Unlimited
    • In vivo synthesis of skin Unlimited
    • In vivo synthesis of peripheral nerve Unlimited
    • Rules for synthesis of tissues and organs Unlimited
    • Joints and dental tissues: prosthetic replacement Unlimited
    • Implants for bone regeneration Unlimited
    • Biomaterial applications in the heart and other organs Unlimited

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Massachusetts Institute of Technology
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