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Last updated:

October 11, 2022

Duration:

Unlimited Duration

FREE

This course includes:

Unlimited Duration

Badge on Completion

Certificate of completion

Unlimited Duration

Description

The course focuses on casting contemporary problems in systems biology and functional genomics in computational terms and providing appropriate tools and methods to solve them.

Topics include genome structure and function, transcriptional regulation, and stem cell biology in particular; measurement technologies such as microarrays (expression, protein-DNA interactions, chromatin structure); statistical data analysis, predictive and causal inference, and experiment design. The emphasis is on coupling problem structures (biological questions) with appropriate computational approaches.

Course Curriculum

    • Course Introduction Unlimited
    • Pairwise Alignment Unlimited
    • Finding Regulatory Sequences in DNA: Motif Discovery Unlimited
    • Finding Regulatory Sequences in DNA: Motif Discovery (cont.) Unlimited
    • Microarray Technology Unlimited
    • Expression Arrays, Normalization, and Error Models Unlimited
    • Expression Profiles, Clustering, and Latent Processes Unlimited
    • Computational Functional Genomics Unlimited
    • Part One: An Example of Clustering Expression Data Unlimited
    • Part Two: Computational Functional Genomics (cont.) Unlimited
    • Computational Discovery of Regulatory Networks Unlimited
    • RNA Silencing Unlimited
    • Computational Functional Genomics (cont.) Unlimited
    • Human Regulatory Networks Unlimited
    • Causal Models Unlimited
    • Causal Bayesian Networks, Active Learning Unlimited
    • From Biological Data to Biological Insight Unlimited
    • Modeling Transcriptional Regulation Unlimited

About the instructor

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Massachusetts Institute of Technology
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