Course Objectives

After taking the course in Infectious Diseases Epidemiology students will be able to describe and understand the main Epidemiological characteristics of the Major infectious diseases of Humans.
The students will be able to describe how these Epidemiological characteristics can be utilized to develop and evaluate strategies to prevent epidemics or endemic transmission of the major infections of humans.
The students will be able to develop criteria to be used in the investigation of a new Emerging or Re-emerging Infectious disease to understand the critical Epidemiologic features of this disease that could be used to develop prevention and control programs. Epidemiological characteristics such as Incubation period, Infectious period, means of transmission and reservoir of these infectious diseases will be evaluated

Prerequisites

Knowledge of basic epidemiology

Textbooks

Kenrad E. Nelson & Carolyn Masters Williams. Infectious Disease Epidemiology: Theory and Practice. Second Edition. Jones and Bartlett Publishers, 2006. This text is designed to be used in the course; book chapters have been written by the course lecturers.

Topic	Readings
Overview of Microbiology	Ksiazek TG, Erdman D et al. A novel coronavirus associated with severe acute respiratory syndrome. New Engl J Med 2003;348(20):1953-1966
The Molecular Epidemiology of Infectious Disease	van rie A, Warren R, Richardson M, Victor TC, Gie RP, Enarson DA, Beyers N, van Helden PD. Exogenous reinfection as cause of recurrent tuberculosis after curative treatment. New Engl J Med 1999;341(15):1174-1179.
Modeling of Infectious Disease	Huges JP, Garnett GP, et al. The theoretical population-level impact of a prophylactic human papilloma virus vaccine. Epidemiology 2002; 13:631-639.
Case-Control Studies	Arcari C, Gaydos CA , Nieto FJ, Krauss M and Nelson KE. Association between Chlamydia pneumoniae and acute myocardial infarction in young men in the United States military: the importance of timing of exposure measurement. Clin Infect Dis 2005; 40:1123-30. Wheeler C, Vogt TM, Armstrong GL et al. An outbreak of hepatitis A associated with green onions. N Engl J Med 2005; 353:890-7.
Vaccines - Impact, Questions, and Challenges	Harper DM, Franco EL. Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infectin with human papillomavirus types 16 and 18 in young women: a randomized controlled trial. Lancet 2004 (364):1757-1765.
Measles	Parker AA, Staggs W, et al. Implications of a 2005 measles outbreak in Indiana for sustained elimination of measles in the United States . New Engl J Med 2006;355(5):447-455.
Disease Eradication	Alexander LN , Seward JF, et al. Vaccine policy changes and epidemiology of poliomyelitis in the United States . JAMA 2004; 292:1696-1701.
Beyond Osler: The Past, Present, and Future of Infection Control	Srinivasan A, Wolfenden LL, Song X, Mackie K, Hartsell TL, Jones HD, Diette GB, Orens JB, Yung RC, Ross TL, Merz W, Scheel PJ, Haponik EF, Perl TM.. An outbreak of Pseudomonas aeruginosa infections associated with flexible bronchoscopes. N Engl J Med 2003;348:91-2.
Interactions between Nutrition and Infection in the Developing World	Fawzi WW, Masamanga GI, Spielman D, et al. A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med 2004; 351:23-32
Epidemiology of Diarrheal Diseases	Woo PCY, Lau SKP, et al. Association of Laribacter hongkongensis in community-acquired gastroenteritis with travel and eating fish: a multicentre case control study. Lancet 2004 (363) 1941-1947.
TB Epidemiology	Weis SE, Slocum Pc, Blais FX, King B, Nunn M, et al. the effect of directly observed therapy on the rates of drug resistance and relapse in tuberculosis. N Engl J Med 1994; 330:1179-1184.
Influenza: Virus and Disease, Epidemics and Pandemics	Horwitz ES, Haber M, Chang A, Shope T, Teo S, Ginsberg M, Waecker N, Cox NJ. Effectiveness of influenza vaccination of day care children in reducing influenza-related morbidity among household contacts. JAMA 2000; 284:1677-1682.
CNS Viral Infections	Stramer SL, Fang CT, Foster GA, Wagner AG, Brodsky JP, Dodd RY. West Nile virus among blood donors in the United States . N Engl J Med 2005; 353:451-9.
Lyme Disease and Its Epidemiology	Steere AC, Sikand VK, Meurice F, Parenti DL, Fikrig EL Schoen RT, Nowakowski J, Schmid CH, Laukamp S, Buscarino C, Krause DS. Lyme Disease Vaccine Study Group. Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. NEJM 1998; 339(4):209-215.
Meningococcal Disease: Global Problem, Local Solutions	Imrey PB, Jackson LA, Ludwinski PH, et al. Outbreak of serogroup C meningococcal disease associated with campus bar patronage. Am J Epidemiol 1996;143:624-30.
Epidemiology and Control of Malaria	Alonso PI, Sacarlal J, et al. Efficacy of the RTS,S/ASO2A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial. Lancet 2004 (364):1411-1420.
STD Epidemiology	Wawer MJ, RH Gray et al. Rates of HIV-1 transmission per Coital Act, by stage of HIV-1 infection, in Rakai, Uganda. JID 2005:191:1403-1409.
The Epidemiology of Hepatitis B and A Infections	Chang M-H, Chen C-J, Lai M-S, Hsu H-M, Wu T-C, Kong M-S, Liang D-C, Shau W-Y, Chen D-S, Taiwan Childhood Hepatoma Study Group. Universal hepatitis B vaccination in Taiwan and the incidence of hepatocellular carcinoma in children. NEJM 1997; 336:1855-1859.
Hepatitis C and E	El-Serag HB, Davila JA, Peterson NJ, McGlynn KA. The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann Intern Med 2003;139:817-823. El-Serag HB, Mason AC. Risk factors for the rising rates of primary liver cancer in the United States. Arch Intern Med 2000; 160:3227-30.

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