Introduces the theory and application of modern, computationally-based methods for exploring and drawing inferences from data. Covers re-sampling methods, non-parametric regression, prediction, and dimension reduction and clustering. Specific topics include Monte Carlo simulation, bootstrap cross-validation, splines, locally weighted regression, CART, random forests, neural networks, support vector machines, and hierarchical clustering. De-emphasizes proofs and replaces them with an extended discussion of the interpretation of results and simulation and data analysis for illustration.