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CHEM 125B: Freshman Organic Chemistry II (Spring 2011, Open Yale Courses). Instructor: Professor J. Michael McBride.
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Description
This is a continuation of Freshman Organic Chemistry I (CHEM 125A), the introductory course on current theories of structure and mechanism in organic chemistry for students with excellent preparation in chemistry and physics. This semester treats simple and complex reaction mechanisms, spectroscopy, organic synthesis, and some molecules of nature. (from oyc.yale.edu)
Course content
- Lecture 01 – Mechanism: How Energies and Kinetic Order Influence Reaction Rates Unlimited
- Lecture 02 – Peculiar Rate Laws, Bond Dissociation Energies, and Relative Reactivities Unlimited
- Lecture 03 – Rate and Selectivity in Radical-Chain Reactions Unlimited
- Lecture 04 – Electronegativity, Bond Strength, Electrostatics, and Non-Bonded Interactions Unlimited
- Lecture 05 – Solvation, H-Bonding, and Ionophores Unlimited
- Lecture 06 – Bronsted Acidity and the Generality of Nucleophilic Substitution Unlimited
- Lecture 07 – Nucleophilic Substitution Tools – Stereochemistry, Rate Law, Substrate Unlimited
- Lecture 08 – Solvent, Leaving Group, Bridgehead Substitution, and Pentavalent Carbon Unlimited
- Lecture 09 – Pentavalent Carbon? E2, SN1, E1 Unlimited
- Lecture 10 – Cation Intermediates – Alkenes: Formation, Addition, and Stability Unlimited
- Lecture 11 – Carbocations and the Mechanism of Electrophilic Addition to Alkenes Unlimited
- Lecture 12 – Nucleophilic Participation During Electrophilic Addition to Alkenes Unlimited
- Lecture 13 – Addition to Form Three-Membered Rings: Carbenoids and Epoxidation Unlimited
- Lecture 14 – Epoxide Opening, Dipolar Cycloaddition, and Ozonolysis Unlimited
- Lecture 15 – Metals and Catalysis in Alkene Oxidation, Hydrogenation, Metathesis Unlimited
- Lecture 16 – Isoprenoids, Rubber, and Tuning Polymer Properties Unlimited
- Lecture 17 – Alkynes; Conjugation in Allylic Intermediates and Dienes Unlimited
- Lecture 18 – Linear and Cyclic Conjugation Theory; 4n+2 Aromaticity Unlimited
- Lecture 19 – Aromatic Transition States: Cycloaddition and Electrocyclic Reactions Unlimited
- Lecture 20 – Electronic and Vibrational Spectroscopy Unlimited
- Lecture 21 – Functional Groups and Fingerprints in IR Spectroscopy Unlimited
- Lecture 22 – Medical MRI and Chemical NMR Unlimited
- Lecture 23 – Diamagnetic Anisotropy and Spin-Spin Splitting Unlimited
- Lecture 24 – Higher-Order Effects, Dynamics, and the NMR Time Scale Unlimited
- Lecture 25 – C-13 and 2D NMR – Electrophilic Aromatic Substitution Unlimited
- Lecture 26 – Aromatic Substitution in Synthesis: Friedel-Crafts and Moses Gomberg Unlimited
- Lecture 27 – Triphenylmethyl and an Introduction to Carbonyl Chemistry Unlimited
- Lecture 28 – Mechanism and Equilibrium of Carbonyl Reactions Unlimited
- Lecture 29 – Imines and Enamines; Oxidation and Reduction Unlimited
- Lecture 30 – Oxidation States and Mechanisms Unlimited
- Lecture 31 – Periodate Cleavage, Retrosynthesis, and Green Chemistry Unlimited
- Lecture 32 – Measuring Bond Energies: Guest Lecture by Prof. G. Barney Ellison Unlimited
- Lecture 33 – Green Chemistry; Acids and Acid Derivatives Unlimited
- Lecture 34 – Acids and Acid Derivatives Unlimited
- Lecture 35 – Acyl Insertions and alpha-Reactivity Unlimited
- Lecture 36 – alpha-Reactivity and Condensation Reactions Unlimited
- Lecture 37 – Proving the Configuration of Glucose and Synthesizing Two Unnatural Products Unlimited
- Lecture 38 – Review: Synthesis of Cortisone Unlimited
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