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This course, Intracellular transport, explains the function of the cytoskeleton and its role in controlling transport of vesicles between different subcellular compartments.

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OpenCoursa

April 21, 2022

UK

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Last updated:

April 21, 2022

Duration:

Unlimited Duration

FREE

This course includes:

Unlimited Duration

Badge on Completion

Certificate of completion

Unlimited Duration

Description

This course, Intracellular transport, explains the function of the cytoskeleton and its role in controlling transport of vesicles between different subcellular compartments.

Course learning outcomes

After studying this course, you should be able to:

  • Define and use each of the terms printed in bold in the text
  • Describe the characteristics of different intracellular compartments with respect to their structure, location and composition within a mammalian cell
  • Describe the traffic pathways between the endoplasmic reticulum, the Golgi apparatus, the endosomal compartments, and the basolateral and apical regions of the plasma membrane
  • Give examples of regulated and unregulated secretion, the mechanisms controlling the processes, and their functional significance
  • Give examples of endocytosis, the mechanisms involved and their functional significance.

Course Curriculum

  • Introduction 00:10:00
  • Learning outcomes 00:10:00
    • Microtubules and microfilaments 00:20:00
    • Polymerisation and depolymerisation of actin 00:40:00
    • Polymerisation and depolymerisation of tubulin 00:30:00
    • Specialised intermediate filaments 00:30:00
    • Summary 00:15:00
    • Introduction 00:35:00
    • Traffic in the endoplasmic reticulum and the Golgi network 00:20:00
    • Sorting for the basolateral and apical zones of the plasma membrane 00:20:00
    • Exocytosis and the secretory pathways 00:30:00
    • The endocytic pathways and lysosomes 00:25:00
    • Transcytosis 00:25:00
    • Summary 00:10:00
    • Introduction 00:45:00
    • Formation of clathrin and COP-coated vesicles 00:50:00
    • Fusion of vesicles with the target membrane 00:50:00
    • The function of Rab proteins in directing traffic 00:25:00
    • Cycling and re-use of membranes and traffic proteins 00:45:00
    • Membrane fusion mediated by viral proteins 00:25:00
    • Summary 00:15:00
    • Introduction 00:10:00
    • Peptide signal sequences 00:20:00
    • Glycosylation sequences and protein glycosylation 00:30:00
    • Lipidation 00:15:00
    • Summary 00:07:00
    • The role of the cytoskeleton in intracellular transport 00:15:00
    • Motor proteins 00:50:00
    • Summary 00:10:00
    • Introduction 00:07:00
    • Endocytosis 00:45:00
    • Uncoupling and receptor recycling 00:25:00
    • Phagocytosis 00:30:00
    • Lysosomes 00:20:00
    • Special endosomal compartments 00:25:00
    • Summary 00:15:00
    • Introduction 00:25:00
    • Triggering systems 00:30:00
    • Regulation of secretion 00:25:00
    • Summary 00:10:00
    • Conclusion 00:03:00

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