It emphasizes the advantages and disadvantages of using these methods in real-world systems and provides hands-on experience. Its technical focus is on decision support, knowledge-based systems (qualitative and quantitative), learning systems (including logistic regression, classification trees, neural networks, rough sets), and techniques to evaluate the performance of such systems. It reviews computer-based diagnosis, planning and monitoring of therapeutic interventions. It also discusses implemented medical applications and the software tools used in their construction. Students produce a final project using the machine learning methods learned in the course, based on actual clinical data.