The goal of multidisciplinary systems design optimization is to create advanced and complex engineering systems that must be competitive not only in terms of performance, but also in terms of life-cycle value. The objective of the course is to present tools and methodologies for performing system optimization in a multidisciplinary design context. Focus will be equally strong on all three aspects of the problem: (i) the multidisciplinary character of engineering systems, (ii) design of these complex systems, and (iii) tools for optimization.