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September 23, 2023

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Description

Principles and Applications of NMR Spectroscopy. Instructor: Prof. Hanudatta S. Atreya, NMR Research Centre, IISc Bangalore.

The objective of the course is to teach the basic aspects of nuclear magnetic resonance (NMR) spectroscopy, which is an important analytical tool in chemical and pharmaceutical industry for structural characterization of molecules. The topics to be covered will include one-dimensional NMR, Chemical shifts, J-coupling, Interpretation of 1D NMR spectrum, Basics of 2D NMR, Different 2D NMR experiments and their application/interpretation, Application of 2D NMR for assignment of molecules and peptides. (from nptel.ac.in)

Course Curriculum

    • Lecture 01 – Instruction to NMR Spectroscopy Unlimited
    • Lecture 02 – The Alignment of Nuclear Spins in Presence of Magnetic Field Unlimited
    • Lecture 03 – Introduction to Rotating Frame Unlimited
    • Lecture 04 – Free Induction Decay and Fourier Transformation of FID Unlimited
    • Lecture 05 – NMR Hardware Unlimited
    • Lecture 06 – The Concept of Chemical Shift Unlimited
    • Lecture 07 – Factors that Affect Chemical Shifts Unlimited
    • Lecture 08 – Chemical Shift Referencing Unlimited
    • Lecture 09 – J-Coupling Unlimited
    • Lecture 10 – Recap of Basics Unlimited
    • Lecture 11 – Introduction to General One-Dimensional NMR Experiment Unlimited
    • Lecture 12 – Practical Aspects of Recording a 1D NMR Experiment I Unlimited
    • Lecture 13 – Practical Aspects of Recording a 1D NMR Experiment II Unlimited
    • Lecture 14 – Practical Aspects of Recording a 1D NMR Experiment III Unlimited
    • Lecture 15 – NMR Data Processing Unlimited
    • Lecture 16 – Basic Aspects of 1D Proton NMR Analysis Unlimited
    • Lecture 17 – Analysis of an Example of 1D Proton Spectrum Unlimited
    • Lecture 18 – Analysis of 1D 1H NMR Spectra of Molecules Unlimited
    • Lecture 19 – Analysis of 1D 1H NMR Spectra of Molecules (cont.) Unlimited
    • Lecture 20 – 1D 13C NMR Unlimited
    • Lecture 21 – Why do We Need 2D NMR? Unlimited
    • Lecture 22 – A Qualitative Explanation of How 2D NMR Experiment Works Unlimited
    • Lecture 23 – Principles of 2D COSY and Total Correlation Spectroscopy (2D TOCSY) Unlimited
    • Lecture 24 – 2D NOE Spectroscopy Unlimited
    • Lecture 25 – 2D NOESY and 2D ROESY Unlimited
    • Lecture 26 – What is Heteronuclear Correlation NMR Spectroscopy? Unlimited
    • Lecture 27 – Sensitivity Enhancement of Heternuclei via Polarization Transfer Unlimited
    • Lecture 28 – 2D HMQC and 2D HSQC Unlimited
    • Lecture 29 – Practical Aspects of Recording and Processing 2D HMQC or HSQC Unlimited
    • Lecture 30 – HMQC and its Utility Unlimited
    • Lecture 31 – 2D HSQC TOCSY and its Analysis with Examples Unlimited
    • Lecture 32 – Structure Determination of Molecules by NMR Unlimited
    • Lecture 33 – Structure Determination of Peptides I Unlimited
    • Lecture 34 – Structure Determination of Peptides II Unlimited
    • Lecture 35 – Structure Determination of Peptides III Unlimited
    • Lecture 36 – Chemical Exchange Unlimited
    • Lecture 37 – Hydrogen or Deuterium Exchange Unlimited
    • Lecture 38 – Diffusion Ordered Spectroscopy (DOSY) Unlimited
    • Lecture 39 – Diffusion Ordered Spectroscopy (cont.) Unlimited
    • Lecture 40 – STD NMR for Drug Target Interactions Unlimited

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