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Last updated:

September 28, 2022


Unlimited Duration


This course includes:

Unlimited Duration

Badge on Completion

Certificate of completion

Unlimited Duration


The principles and practice of tissue engineering (and regenerative medicine) are taught by faculty of the Harvard-MIT Division of Health Sciences and Technology (HST) and Tsinghua University, Beijing, China.

The principles underlying strategies for employing selected cells, biomaterial scaffolds, soluble regulators or their genes, and mechanical loading and culture conditions, for the regeneration of tissues and organs in vitro and in vivo are addressed. Differentiated cell types and stem cells are compared and contrasted for this application, as are natural and synthetic scaffolds. Methodology for the preparation of cells and scaffolds in practice is described. The rationale for employing selected growth factors is covered and the techniques for incorporating their genes into the scaffolds are examined. Discussion also addresses the influence of environmental factors including mechanical loading and culture conditions (e.g., static versus dynamic). Methods for fabricating tissue-engineered products and devices for implantation are taught. Examples of tissue engineering-based procedures currently employed clinically are analyzed as case studies.

Archived webcast lecture videos for the Fall 2008 version of this class can be found at the HST.535 Fall 2008 website.

Course Curriculum

    • Introduction to Tissue Engineering in China Unlimited
    • Scaffolds: Introduction Unlimited
    • Scaffolds: Collagen-GAG Analogs of Extracellular Matrix Unlimited
    • Cells: Liver Cells Unlimited
    • Scaffolds: Free-Form Manufacturing Unlimited
    • Scaffolds: Self-Assembled Proteins Unlimited
    • Review Unlimited
    • Cells Unlimited
    • Scaffolds: Biomimetics Design Unlimited
    • Cells: Effects of Culture Conditions Unlimited
    • Review Unlimited
    • Regulators: Gene Transfer Wedded to Tissue Engineering Unlimited
    • Applications: Skin and Peripheral Nerve Regeneration Unlimited
    • Nerve Repair Unlimited
    • Discussion: Clinical Applications Unlimited
    • Discussion: Comparative Analysis of Tissue Engineering Strategies Unlimited
    • Cartilage Repair Unlimited
    • Discussion: Review Unlimited
    • Federal Regulatory Issues for Tissue Engineering Products in the U.S., China, and Other Countries Unlimited

About the instructor


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Massachusetts Institute of Technology
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