This meticulously conducted systematic review delves into the nuanced connections between osteopathy and psychological well-being, shedding light on the intricate interplay between physical and mental dimensions of pain management. Uncover evidence-based insights and transformative perspectives that illuminate the potential of osteopathic interventions to not only alleviate physical discomfort but also enhance the overall psychosocial resilience of those navigating persistent pain. This course is a vital resource for healthcare professionals seeking a holistic understanding of pain management strategies and a nuanced approach to patient care.